However, intravenous infection with the same pathogen induces minimal CD103 expression and reduced residency. monocytogenes infection induces a robust intestinal CD8 T cell response that is predominately composed of memory precursor cells that rapidly upregulate a marker of epithelial T cell residency, CD103. Licensing of resident memory T cell development: Foodborne L.A current project continues to explore how this transcription factor regulates T cell responses. My lab was the first to report that cell intrinsic BATF3 also promotes the development of CD8 T cell memory, in part by regulating apoptosis during the contraction phase of an immune response. BATF3 regulates the development of a conventional DC subset (cDC1) that promotes the induction of effector CD8 T cells during foodborne L. BATF3 regulation of memory T cell development: The transcription factor BATF3 regulates CD8 T cell responses through cell extrinsic and intrinsic pathways.These pathogens provide an excellent opportunity to understand the biology of intestinal T cell immunity and apply this knowledge to human pathogens, inflammatory disorders of the intestines, and gastrointestinal tumors. My lab primarily utilizes foodborne infection with pathogens such as Listeria monocytogenes, Salmonella enterica (Typhimurium), and Yersinia pseudotuberculosis to probe conventional and unconventional T cell responses in the gastrointestinal system. We seek to understand the processes of effector T cell generation, establishment of memory, and memory homeostasis within the intestinal mucosa. My laboratory is focused on elucidating the processes regulating T cell memory in mucosal and barrier tissues. As such, understanding the mechanisms of immunologic protection at this site is essential for designing effective vaccination schemes. Thus, a goal of vaccination against foodborne pathogens is to leverage mucosal T cells to prevent infection. This barrier tissue is also highly enriched with conventional (CD8 and CD4) and unconventional (gamma delta, γδ) T cell populations that are poised for rapid control in case of barrier breach. The major entry point for many human pathogens is through gastrointestinal mucosal surfaces.

Ph.D., Immunology, University of Pittsburgh School of Medicine, 632-4459 Boston College, 1997): 26įollow Rutgers Athletics on Facebook and Twitter for all of the latest news and updates.Department of Microbiology and Immunology He moved to Florida in 2007 and was promoted to head coach at American Heritage last December.Ģ. 1 ranking his final two scholastic seasons.įollowing his playing days, Sheridan became a high school coach in New Jersey, including leading his alma mater, Union, for five seasons. The 1992 New Jersey Gatorade Player of the Year and two-time all-state selection by the Star-Ledger, he led Union High School to perfect 11-0 records and the state's No. Overall, Sheridan recorded 389 career tackles, which ranks third in the RU record book. Making an immediate impact, he registered a 93-yard fumble return for a touchdown to go with an interception in his debut as a true freshman versus Colgate at Giant Stadium in 1993. Sheridan served as a captain for the first time that season, alongside Marco Battaglia, Ray Lucas and Mark Washington. He picked up Big East Defensive Player of the Week following an 18-tackle performance in the win over Navy. Cronin Trophy, an honor recognizing the most improvement and progress on the team, after totaling 132 tackles to pace the defense. He earned Second Team All-Big East honors, as well as the Homer Hazel Award as the most valuable player on the team.Īs a junior in 1995, Sheridan garnered the George T. The linebacker, voted a captain for the second time, posted two of the top four total-tackle games in school history that year with a best of 26 versus Boston College and 23 in the finale at Miami. A native of Union, New Jersey, with over 20 years of coaching experience, Sheridan was the head coach at American Heritage High School in Delray Beach, Florida.Ī four-time letterwinner for the Scarlet Knights (1993-95, 97), Sheridan capped his collegiate career with 161 tackles (109 solo) in 1997, the single-season program standard. – Rutgers mourns the passing of two-time captain Brian Sheridan, who died Tuesday at age 45.

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